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One by One IVF is an innovative, new approach to assisted reproduction that involves freezing all embryos in an IVF cycle and transferring after thawing ‘one-by-one’ in later non-stimulated cycles. This maximises cumulative live birth rates per IVF attempt while minimising multiple pregnancies, which increases the health risks for both mother and baby.

One by One IVF Plus

One by One IVF Plus provides a further level of sophistication by testing embryos for unbalanced chromosomes. Embryos with abnormal numbers of chromosomes or parts of chromosomes are almost always incapable of developing into a pregnancy and healthy baby. These are the most frequent cause of IVF failure and miscarriage, especially in patients of more advanced reproductive age.

Pioneered by the world’s foremost fertility specialists, including our London Bridge team, and only offered by a handful of top clinics world-wide so far, higher cumulative pregnancy rates are being reported for a wide range of maternal ages.

Benefits of One by One IVF

  • High cumulative singleton pregnancy rates of around 75%*
  • Maximising pregnancy rates in a single cycle of IVF
  • A decreasing risk of twin pregnancy which is safer for mother and baby
  • Affordable, inclusive packages, including up to two frozen embryo transfer cycles

Additional Benefits of One by One IVF Plus

  • The transfer of only genetically balanced embryos
  • High cumulative singleton pregnancy rates of around 90%*
  • Reduced pregnancy loss/miscarriage rates 
  • A shorter time to pregnancy than standard IVF

How does One by One IVF work?

One by One IVF incorporates many of the latest innovations in IVF to maximise the chances of a successful and safe single pregnancy:

  • Ovarian stimulation individually tailored to optimise the number of mature eggs collected in a single IVF treatment cycle.
  • Embryos are cultured to the blastocyst stage and monitored by time-lapse imaging.
  • No embryo transfer in the fresh cycle to avoid ovarian hyperstimulation syndrome (OHSS) and improve the chance of pregnancy.
  • All blastocysts are vitrified (frozen) and transferred in a series of frozen embryo transfer.

One by One IVF Plus additionally includes:

  • Unlimited embryo testing for genetic imbalances (aneuploidy and structural abnormalities) by ‘Next Generation Sequencing’ (NGS) chromosome copy number analysis.
  • Transfer of a genetically balanced blastocyst in a series of single frozen embryo transfer cycles.

* Based on historical cumulative results and ongoing One  by One IVF success rates

 

Success Rates

These statistics show our One by One IVF success rates - those that successfully lead to pregnancy. All pregnancies were confirmed for foetal heartbeat by ultrasound scans.

Under 35

Pregnancy rate per embryo transferred

February 2017 - January 2018

National average 36%

35-37

Pregnancy rate per embryo transferred

February 2017 - January 2018

National average 31%

38-39

Pregnancy rate per embryo transferred

February 2017 - January 2018

National average 24%

40-42

Pregnancy rate per embryo transferred

February 2017 - January 2018

National average 18%

Over 42

Pregnancy rate per embryo transferred

February 2017 - January 2018

National average 8%

Three Cycle Package

Package completed 2013

All ages 

No national average available

Under 35

Pregnancy rate per embryo transferred

February 2017 - January 2018

No national average available

35-37

Pregnancy rate per embryo transferred

February 2017 - January 2018

No national average available

38-39

Pregnancy rate per embryo transferred

February 2017 - January 2018

No national average available

40-42

Pregnancy rate per embryo transferred

February 2017 - January 2018

No national average available

Over 42

Pregnancy rate per embryo transferred

February 2017 - January 2018

No national average available

Under 35

Cumulative pregnancy rate per cycle (n=12)

March 2016 - February 2018

No national average available

35-37

Cumulative pregnancy rate per cycle (n=20)

March 2016 - February 2018

No national average available

38-39

Cumulative pregnancy rate per cycle (n=18)

March 2016 - February 2018

No national average available

40-42

Cumulative pregnancy rate per cycle (n=13)

March 2016 - February 2018

No national average available

43 and over

Cumulative pregnancy rate per cycle (n=5)

March 2016 - February 2018

No national average available

Fresh donor eggs

Pregnancy rate per embryo transferred

January 2016 - December 2017

National average 44%

Frozen donor eggs

Pregnancy rate per embryo transferred

January 2016 - December 2017

No national average available

Intra-partner

Pregnancy rate per embryo transferred (n=22)

February 2017 - January 2018

National average 44%

Egg-sharing (recipient)

Pregnancy rate per embryo transferred (n=5)

February 2017 - January 2018

National average 44%

Under 35 Natural Cycle

Clinical pregnancy rate (n=21)

February 2017 - January 2018

No national average available

All Ages Natural Cycle

Clinical pregnancy rate (n=49)

February 2017 - January 2018

No national average available

Under 35 Stimulated Cycle

Clinical pregnancy rate (n=32)

February 2017 - January 2018

No national average available

All Ages Stimulated Cycle

Clinical pregnancy rate

February 2017 - January 2018

No national average available

Under 35 Natural cycle

Clinical pregnancy rate 

February 2017 - January 2018

National average 13%

All Ages Natural Cycle

Clinical pregnancy rate

February 2017 - January 2018

No national average available

Under 35 Stimulated Cycle

Clinical pregnancy rate 

February 2017 - January 2018

National average 15%

All Ages Stimulated Cycle

Clinical pregnancy rate

February 2017 - January 2018

No national average available

Meet the One by One IVF team

Our dedicated team has over 25 years experience in fertility and genetics

Mr Michel Summers, Consultant in Reproductive Medicine

A graduate of King’s College, Cambridge Mr Summers completed his medical training at the University of Pennsylvania School of Medicine followed by a Clinical Fellowship in Reproductive Endocrinology and Infertility at the Brigham and Women’s Hospital, Harvard Medical School. He is certified by both the American College of Obstetrics and Gynaecology (ACOG) as well as on the GMC Specialist Register as a Consultant in Reproductive Medicine. His special interests include IVF, embryo culture, embryo implantation and preimplantation genetic diagnostics, areas of research in which he has published extensively.

Professor Alan Handyside, Consultant in Pre-implantation Genetics

Professor Handyside is a leading scientist in human embryology and the genetics of early human development having pioneered the development of Preimplantation Genetic Diagnosis (PGD) and Genetic Embryo Testing for chromosome aneuploidy - two groundbreaking techniques for identifying genetic abnormality and for assisting embryo selection. He supports team in all aspects of patient care and continues to lead important developments in embryo assessment.

Dr Julija Gorodeckaja, Fertility and IVF Specialist

Dr Gorodeckaja trained in obstetrics and gynaecology at the Vilnius University Hospital in Lithuania. Since moving to the UK in 2012, she has worked at the Whittington Hospital as a specialist trainee, at the Baltic Medical Centre and at the Kings College Hospital as a clinical fellow. Her specialist interests are in preimplantation genetics (PGS), advanced gynaecological scanning and early pregnancy diagnostics.

Jinjun Wang, Laboratory Manager and Senior Embryologist

Jinjun received his embryology training from the Shenzhen Hospital of Beijing University and Sydney. He has been a member of the team at LWC since 2008 and became Laboratory Manager in 2013. His objective is to maintain the high success rate of the laboratory and introduce new technologies - such as oocyte vitrification and blastomere biopsy - for the benefit of LWC patients.

Elena Linara, Senior Embryologist and Quality Lead

Elena has 10 years’ experience within embryology and is qualified in biomedical sciences, prenatal genetics and fetal medicine, and clinical embryology. She is particularly interested in ocyte and embryo vitrification, prenatal genetics, quality management, intrauterine insemination and egg sharing. Before joining the team at LWC she worked as an embryologist, andrologist and a deputy sperm bank manager.

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