A recent abstract accepted for Fertility 2026 highlights how advanced sperm selection techniques can improve IVF outcomes, particularly in donor egg cycles. At London Women’s Clinic, we know that sperm quality is a critical—but sometimes overlooked—factor in IVF success. Healthy sperm DNA and motility are essential for fertilisation and embryo development, and selecting the highest-quality sperm can make a meaningful difference when sperm quality may be compromised.

Advanced Sperm Selection Techniques at LWC

The study explored the combined use of microfluidics (ZYMOT) and physiological ICSI (PICSI) compared to conventional sperm preparation methods. Here’s what the research revealed:

• Microfluidics (ZYMOT): This technique filters sperm to isolate those with superior DNA integrity and motility, giving embryos the strongest possible start.

• Physiological ICSI (PICSI): Sperm are placed in a hyaluronan-based dish, and those that bind most strongly are selected for injection. Binding indicates sperm maturity and quality, helping choose the best candidates for fertilisation.

• Combined approach: Using both ZYMOT and PICSI resulted in the highest rates of fertilisation, embryo formation and pregnancy, outperforming routine selection techniques.

• Clinical impact: This approach offers a valuable tool for patients facing male factor infertility or other challenges affecting sperm quality.

These findings underscore the potential of advanced sperm selection to improve IVF outcomes. They also reflect London Women’s Clinic’s ongoing commitment to evidence-based innovation, patient-focused care and leadership in reproductive medicine.

Study reference:
Linara-Demakakou E, Katundi E, Chivers A, Georgakas A, Macklon N, Ahuja K. Combined use of microfluidics and physiological ICSI (PICSI) for enhanced sperm selection and improved pregnancy outcomes in donor oocyte cycles. Abstract accepted for Fertility 2026.