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Why screen embryos

Many IVF cycles result in disappointment as the embryos fail to implant or the pregnancy ends in spontaneous miscarriage, particularly when the female partner is over 35. We now know that many of the transferred embryos - as many as 50% - are genetically abnormal (chromosomally unbalanced).

PGS

Traditionally, embryos are chosen according to their appearance under the microscope after three or five days of development in the incubator. However, in the past few years additional techniques of selection have been introduced which use high-tech methods to screen embryos for genetic and chromosomal information. The latest techniques of embryo screening use a method known as ‘next generation sequencing’. All chromosomes can be assessed and only embryos identified at low risk of chromosome abnormalities are selected for embryo transfer.

One by One IVF

Pioneered by only a handful of top clinics world-wide so far, One by One IVF is an innovative, new approach to assisted reproduction that involves freezing all embryos in an IVF cycle and transferring after thawing ‘one-by-one’ in later non-stimulated cycles. Prior to freezing, embryos are screened using the technique of ‘next generation sequencing’ by testing embryos for unbalanced chromosomes.  This maximises cumulative live birth rates per IVF attempt while minimising multiple pregnancies, which increases the health risks for both mother and baby.

PGD

The technique of preimplantation genetic diagnosis (PGD) can be performed successfully in couples who are known to be at risk of passing on an inherited genetic disease to their children; however, this is a complex and demanding treatment, and appropriate only for couples known to be carriers of a genetic mutation.

PGD has revolutionised the prospects of parenthood for couples who are known carriers of, for example, the cystic fibrosis gene mutation. By identifying and transferring those embryos without the mutation, carrier couples can be reassured that their baby will not be affected by a severe genetic condition.  This technique provides an alternative to prenatal testing by CVS or amniocentesis - and thus prevents termination at a later stage of pregnancy.

 

Success Rates

These statistics show our One by One IVF success rates - those that successfully lead to pregnancy. All pregnancies were confirmed for foetal heartbeat by ultrasound scans.

Under 35

Pregnancy rate per embryo transferred

February 2017 - January 2018

National average 36%

35-37

Pregnancy rate per embryo transferred

February 2017 - January 2018

National average 31%

38-39

Pregnancy rate per embryo transferred

February 2017 - January 2018

National average 24%

40-42

Pregnancy rate per embryo transferred

February 2017 - January 2018

National average 18%

Over 42

Pregnancy rate per embryo transferred

February 2017 - January 2018

National average 8%

Three Cycle Package

Package completed 2013

All ages 

No national average available

Under 35

Pregnancy rate per embryo transferred

February 2017 - January 2018

No national average available

35-37

Pregnancy rate per embryo transferred

February 2017 - January 2018

No national average available

38-39

Pregnancy rate per embryo transferred

February 2017 - January 2018

No national average available

40-42

Pregnancy rate per embryo transferred

February 2017 - January 2018

No national average available

Over 42

Pregnancy rate per embryo transferred

February 2017 - January 2018

No national average available

Under 35

Cumulative pregnancy rate per cycle (n=12)

March 2016 - February 2018

No national average available 

35-37

Cumulative pregnancy rate per cycle (n=20)

March 2016 - February 2018

No national average available 

38-39

Cumulative pregnancy rate per cycle (n=18)

March 2016 - February 2018

No national average available 

40-42

Cumulative pregnancy rate per cycle (n=13)

March 2016 - February 2018

No national average available 

43 and over

Cumulative pregnancy rate per cycle (n=5)

March 2016 - February 2018

No national average available 

Fresh donor eggs

Pregnancy rate per embryo transferred

January 2016 - December 2017

National average 44%

Frozen donor eggs

Pregnancy rate per embryo transferred

January 2016 - December 2017

No national average available

Intra-partner

Pregnancy rate per embryo transferred (n=22)

February 2017 - January 2018

National average 44%

Egg-sharing (recipient)

Pregnancy rate per embryo transferred (n=5)

February 2017 - January 2018

National average 44%

Under 35 Natural Cycle

Clinical pregnancy rate (n=21)

February 2017 - January 2018

No national average available

All Ages Natural Cycle

Clinical pregnancy rate (n=49)

February 2017 - January 2018

No national average available

Under 35 Stimulated Cycle

Clinical pregnancy rate (n=32)

February 2017 - January 2018

No national average available

All Ages Stimulated Cycle

Clinical pregnancy rate

February 2017 - January 2018

No national average available

Under 35 Natural cycle

Clinical pregnancy rate 

February 2017 - January 2018

National average 13%

All Ages Natural Cycle

Clinical pregnancy rate

February 2017 - January 2018

No national average available

Under 35 Stimulated Cycle

Clinical pregnancy rate 

February 2017 - January 2018

National average 15%

All Ages Stimulated Cycle

Clinical pregnancy rate

February 2017 - January 2018

No national average available

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